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Japanese Wasabi and Horseradish: What Is the Difference, and Where Does Hexaraphane Come From?
Hexaraphane
9 min read
Japanese Wasabi and Horseradish: What Is the Difference, and Where Does Hexaraphane Come From?
This article outlines the differences between Japanese wasabi and horseradish, explains that hexaraphane is abundant in the rhizome of Japanese wasabi, and discusses why ordinary shelf-stable tube wasabi is unlikely to serve as a source of this compound.
Aging Research in 2026: How Far Has the Science of Slowing Aging Come?
13 min read
Aging Research in 2026: How Far Has the Science of Slowing Aging Come?
An overview of recent aging research from the perspectives of interconnected bodily mechanisms, cellular resilience, lifestyle, and individual differences—explaining where the field stands and how to interpret it.
Hexaraphane Simultaneously Inhibits Keap1 and Gsk-3β: New Evidence for Dual-Pathway Nrf2 Activation
Hexaraphane
9 min read
Hexaraphane Simultaneously Inhibits Keap1 and Gsk-3β: New Evidence for Dual-Pathway Nrf2 Activation
This article examines a 2025 preclinical study showing that hexaraphane (6-MSITC) from Japanese wasabi may activate Nrf2 through two pathways: Keap1 inhibition and direct Gsk-3β inhibition. It also discusses differences from sulforaphane and implications for chronic disease research.